1838592-80-5
Chemical Structure
TPP2a bromide
- CAS No.: 1838592-80-5
- Formula:C47H52BrO5P
- Molecular Weight:807.79
IUPAC Name: (10-(4-((1E,4Z,6E)-5-hydroxy-7-(5-methylfuran-2-yl)-3-oxohepta-1,4,6-trien-1-yl)-2-methoxyphenoxy)decyl)triphenylphosphonium bromide
InChIKey: LPFQNDVZJVVEPE-SEOIZWFPSA-N
SMILES: O=C(/C=C(/C=C/C1=CC=C(C)O1)O)/C=C/C2=CC=C(C(OC)=C2)OCCCCCCCCCC[P+](C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5.[Br-]
Biological Activity: TPP2a bromide is a thioredoxin reductase (TrxR) inhibitor with an IC50 value of 1.16 μM, and also acts as a TrxR-specific fluorescent probe with environment-sensitive fluorescence. TPP2a bromide selectively forms covalent interactions with subcellular mitochondrial TrxR, thereby modifying its Sec498 residue. TPP2a bromide can increase the level of reactive oxygen species (ROS) in cells and induce mitochondrial apoptosis in cancer cells. TPP2a bromide exhibits enhanced cytotoxicity against cancer cell lines. TPP2a bromide can be used in research related to cervical cancer, lung cancer, etc[1].
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TPP2a bromide | TPP2a bromide is a thioredoxin reductase (TrxR) inhibitor with an IC50 value of 1.16 μM, and also acts as a TrxR-specific fluorescent probe with environment-sensitive fluorescence. TPP2a bromide selectively forms covalent interactions with subcellular mitochondrial TrxR, thereby modifying its Sec498 residue. TPP2a bromide can increase the level of reactive oxygen species (ROS) in cells and induce mitochondrial apoptosis in cancer cells. TPP2a bromide exhibits enhanced cytotoxicity against cancer cell lines. TPP2a bromide can be used in research related to cervical cancer, lung cancer, etc. | |||||||||||||||||||||
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