1842371-08-7
1842371-08-7
Chemical Structure
PF-06764427
- CAS No.: 1842371-08-7
- Formula:C24H25N5O3
- Molecular Weight:431.49
IUPAC Name: N-((3R,4S)-3-hydroxytetrahydro-2H-pyran-4-yl)-1-(4-(1-methyl-1H-pyrazol-3-yl)benzyl)-1H-pyrrolo[3,2-b]pyridine-3-carboxamide
InChIKey: FQGJDGJXEZTKDW-UNMCSNQZSA-N
SMILES: O=C(C1=CN(CC2=CC=C(C3=NN(C)C=C3)C=C2)C4=CC=CN=C41)N[C@@H]5[C@@H](O)COCC5
Biological Activity: PF-06764427 is a selective M1 muscarinic acetylcholine receptor positive allosteric modulator. PF-06764427 exhibits robust M1 agonist activity. PF-06764427 can be used in the research of Alzheimer's disease and schizophrenia[1][2].
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PF-06764427 | PF-06764427 is a selective M1 muscarinic acetylcholine receptor positive allosteric modulator. PF-06764427 exhibits robust M1 agonist activity. PF-06764427 can be used in the research of Alzheimer's disease and schizophrenia. | |||||||||||||||||||||
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References
- [1]. Davoren JE, et al. Design and optimization of selective azaindole amide M1 positive allosteric modulators. Bioorg Med Chem Lett. 2016 Jan 15;26(2):650-655. [Content Brief]
- [2]. Moran SP, et al. M1-positive allosteric modulators lacking agonist activity provide the optimal profile for enhancing cognition. Neuropsychopharmacology. 2018 Jul;43(8):1763-1771. [Content Brief]
Keywords
