186036-91-9
Chemical Structure
11F-CPT
- CAS No.: 186036-91-9
- Formula:C20H15FN2O4
- Molecular Weight:366.34
InChIKey: SGYUZUFGKXEXQO-FQEVSTJZSA-N
SMILES: O=C1C2=C([C@](CC)(O)C(OC2)=O)C=C3C4=NC5=CC(F)=CC=C5C=C4CN31
Biological Activity: 11F-CPT is a Topoisomerase I inhibitor that stabilizes the TOP I-DNA cleavage complex. 11F-CPT inhibits TOP I-mediated DNA relaxation, induces DNA damage, and activates ATR-CHK1 signaling. 11F-CPT selectively inhibits proliferation and colony formation in pancreatic cancer cells, upregulates γ‑H2AX, and induces cell cycle arrest and apoptosis. 11F-CPT inhibits tumor growth in the PAN02 pancreatic cancer xenograft model and enhances the thermal stability of TOP I in cells. 11F-CPT can be used for research on pancreatic cancer[1].
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11F-CPT | 11F-CPT is a Topoisomerase I inhibitor that stabilizes the TOP I-DNA cleavage complex. 11F-CPT inhibits TOP I-mediated DNA relaxation, induces DNA damage, and activates ATR-CHK1 signaling. 11F-CPT selectively inhibits proliferation and colony formation in pancreatic cancer cells, upregulates γ‑H2AX, and induces cell cycle arrest and apoptosis. 11F-CPT inhibits tumor growth in the PAN02 pancreatic cancer xenograft model and enhances the thermal stability of TOP I in cells. 11F-CPT can be used for research on pancreatic cancer. | |||||||||||||||||||||
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