1862177-86-3
1862177-86-3
Chemical Structure
COB-187
- CAS No.: 1862177-86-3
- Formula:C15H14N2OS2
- Molecular Weight:302.41
InChIKey: RPAZLTQZYXMTQP-UHFFFAOYSA-N
SMILES: OC1(CSC(N1CC2=CC=NC=C2)=S)C3=CC=CC=C3
Biological Activity: COB-187 is a potent, ATP-competitive and selective inhibitor of GSK-3β. COB-187 inhibits GSK-3 through a reversible and Cysteine (Cys)-199-dependent mechanism. COB-187 inhibits LPS induced cytokine production and SARS-CoV-2 spike protein-induced CXCL10 production[1].
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COB-187 | 95.0% | COB-187 is a potent, ATP-competitive and selective inhibitor of GSK-3β. COB-187 inhibits GSK-3 through a reversible and Cysteine (Cys)-199-dependent mechanism. COB-187 inhibits LPS induced cytokine production and SARS-CoV-2 spike protein-induced CXCL10 production. | ||||||||||||||||||||
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References
Keywords
