186350-27-6
186350-27-6
Chemical Structure
EUK-189
- CAS 番号: 186350-27-6
- Formula:C22H25MnN2O6
- Molecular Weight:468.38
InChIKey: KXTUTHZAUZDAFX-FDOBHKDXSA-K
SMILES: CC([O-][Mn+3]12([N]3=CC4=CC=CC(OCC)=C4[O-]2)[N](CC3)=CC5=C(C(OCC)=CC=C5)[O-]1)=O
Biological Activity: EUK-189 is a synthetic superoxide dismutase (SOD) and catalase mimetic. EUK-189 can block oxygen/glucose deprivation (OGD)-induced ERK1/2 dephosphorylation, ATP depletion and eliminate ROS production. EUK-189 exhibits neuroprotective effect and can inhibit delayed radiation injury. EUK-189 can be used for the research of neurological disease, such as ischemic stroke[1][2].
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EUK-189 | EUK-189 is a synthetic superoxide dismutase (SOD) and catalase mimetic. EUK-189 can block oxygen/glucose deprivation (OGD)-induced ERK1/2 dephosphorylation, ATP depletion and eliminate ROS production. EUK-189 exhibits neuroprotective effect and can inhibit delayed radiation injury. EUK-189 can be used for the research of neurological disease, such as ischemic stroke. | |||||||||||||||||||||
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References
- [1]. Zhou M, et al. Superoxide dismutase/catalase mimetics but not MAP kinase inhibitors are neuroprotective against oxygen/glucose deprivation-induced neuronal death in hippocampus. J Neurochem. 2007 Dec;103(6):2212-23. [Content Brief]
- [2]. Rosenthal RA, et al. Salen Mn complexes mitigate radiation injury in normal tissues. Anticancer Agents Med Chem. 2011 May 1;11(4):359-72. [Content Brief]
