18791-21-4
Chemical Structure
Pyridomycin
Synonym(s): Erizomycin; NSC 246134
- CAS No.: 18791-21-4
- Formula:C27H32N4O8
- Molecular Weight:540.56
IUPAC Name: N-((5R,6S,9S,10S,11R,Z)-2-(butan-2-ylidene)-10-hydroxy-5,11-dimethyl-3,7,12-trioxo-9-(pyridin-3-ylmethyl)-1,4-dioxa-8-azacyclododecan-6-yl)-3-hydroxypicolinamide
InChIKey: WHIKSLGSXKIHCA-IGCCMALHSA-N
SMILES: O=C(C1=NC=CC=C1O)N[C@H](C(N[C@@H](CC2=CC=CN=C2)[C@@H](O)[C@H]3C)=O)[C@@H](C)OC(/C(OC3=O)=C(C)/CC)=O
Biological Activity: Pyridomycin (Erizomycin) is a selective and low cytotoxic inhibitor of Mycobacterium tuberculosis that effectively targets InhA. Pyrdomycin is also an antibiotic that can be obtained from metabolites of Dactylosporangium fulvum. Pyrdomycin can be used in the study of bacterial infections such as tuberculosis[1][2].
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Pyridomycin | Pyridomycin (Erizomycin) is a selective and low cytotoxic inhibitor of Mycobacterium tuberculosis that effectively targets InhA. Pyrdomycin is also an antibiotic that can be obtained from metabolites of Dactylosporangium fulvum. Pyrdomycin can be used in the study of bacterial infections such as tuberculosis. | |||||||||||||||||||||
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- [1]. Hartkoorn RC, et al. Towards a new tuberculosis drug: pyridomycin - nature's isoniazid. EMBO Mol Med. 2012 Oct;4(10):1032-42. [Content Brief]
- [2]. Hartkoorn RC, et al. Pyridomycin bridges the NADH- and substrate-binding pockets of the enoyl reductase InhA. Nat Chem Biol. 2014 Feb;10(2):96-8. [Content Brief]
Keywords
