18866-78-9
18866-78-9
Chemical Structure
Colterol
- CAS No.: 18866-78-9
- Formula:C12H19NO3
- Molecular Weight:225.28
IUPAC Name: 4-(2-(tert-butylamino)-1-hydroxyethyl)benzene-1,2-diol
InChIKey: PHSMOUBHYUFTDM-UHFFFAOYSA-N
SMILES: OC1=CC=C(C(O)CNC(C)(C)C)C=C1O
Biological Activity: Colterol is the agonist for adrenergic receptor, and exhibits good affinity to β1-adrenoreceptor (heart) and β2-adrenoreceptor (lung) with IC50 of 645 nM and 147 nM. Colterol exhibits potential as a bronchodilator[1][2].
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Colterol | Colterol is the agonist for adrenergic receptor, and exhibits good affinity to β1-adrenoreceptor (heart) and β2-adrenoreceptor (lung) with IC50 of 645 nM and 147 nM. Colterol exhibits potential as a bronchodilator. | |||||||||||||||||||||
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References
- [1]. Kusayama T, et al., Binding of a catechol derivative of denopamine (T-0509) and N-tert-butylnoradrenaline (Colterol) to beta 1- and beta 2-adrenoceptors. Biol Pharm Bull. 1994 Aug;17(8):1023-7. [Content Brief]
- [2]. Walker SB, et al., Bitolterol mesylate: a beta-adrenergic agent. Chemistry, pharmacokinetics, pharmacodynamics, adverse effects and clinical efficacy in asthma. Pharmacotherapy. 1985 May-Jun;5(3):127-37. [Content Brief]
