189224-48-4
189224-48-4
Chemical Structure
KU14R
- CAS No.: 189224-48-4
- Formula:C13H14N2O
- Molecular Weight:214.26
IUPAC Name: 2-(2-ethyl-2,3-dihydrobenzofuran-2-yl)-1H-imidazole
InChIKey: JCWVNNMJXQJVNC-UHFFFAOYSA-N
SMILES: CCC1(C2=NC=CN2)OC3=CC=CC=C3C1
Biological Activity:
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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KU14R | 98.91% | KU14R is a new I(3)-R antagonist, which selectively blocks the insulin secretory response to imidazolines. | ||||||||||||||||||||
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References
- Bozdagi O, Wang XB, Martinelli GP, et al. Imidazoleacetic acid-ribotide induces depression of synaptic responses in hippocampus through activation of imidazoline receptors. J Neurophysiol. 2011,105(3):1266-75. [Content Brief]
- Bleck C, Wienbergen A, Rustenbeck I. Essential role of the imidazoline moiety in the insulinotropic effect but not the KATP channel-blocking effect of imidazolines; a comparison of the effects of efaroxan and its imidazole analogue, KU14R. Diabetologia. 2 [Content Brief]
- Cooper EJ, Hudson AL, Parker CA, et al. Effects of the beta-carbolines, harmane and pinoline, on insulin secretion from isolated human islets of Langerhans. Eur J Pharmacol. 2003;482(1-3):189-96. [Content Brief]
- Mayer G, Taberner PV. Effects of the imidazoline ligands efaroxan and KU14R on blood glucose homeostasis in the mouse. Eur J Pharmacol. 2002;454(1):95-102. [Content Brief]
- Susan L.F Chana, Anna L Palletta, John Clewsb. Evidence that the ability of imidazoline compounds to stimulate insulin secretion is not due to interaction with σ receptors. European Journal of Pharmacology. 1997,323( 2-3): 241-244.
Keywords
