1. Protein Tyrosine Kinase/RTK
  2. Insulin Receptor

KU14R 

Cat. No.: HY-15481
Handling Instructions

KU14R is a new I(3)-R antagonist, which selectively blocks the insulin secretory response to imidazolines.

For research use only. We do not sell to patients.
KU14R Chemical Structure

KU14R Chemical Structure

CAS No. : 189224-48-4

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Description

KU14R is a new I(3)-R antagonist, which selectively blocks the insulin secretory response to imidazolines. IC50 Value: Target: Insulin Receptor A new I(3)-R antagonist, KU14R (2 (2-ethyl 2,3-dihydro-2-benzofuranyl)-2-imidazole), which selectively blocks the insulin secretory response to imidazolines. KU14R partially attenuated responses to Imidazole-4-acetic acid-ribotide (IAA-RP). The effects of KU14R on stimulus secretion-coupling in normal mouse islets and beta cells was compared by measuring KATP channel activity, plasma membrane potential, cytosolic calcium concentration ([Ca2+]c) and dynamic insulin secretion. In the presence of 10 mmol/l but not of 5 mmol/l glucose, KU14R (30, 100 or 300 micromol/l) was ineffective. KATP channel was blocked by KU14R (IC50 31.9 micromol/l, Hill slope -1.5). KU14R does not act as an antagonist of either efaroxan or S22068 at an imidazoline site in vivo.

References
Molecular Weight

214.26

Formula

C₁₃H₁₄N₂O

CAS No.

189224-48-4

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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KU14R
Cat. No.:
HY-15481
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