189353-31-9
Chemical Structure
Fadolmidine
- CAS No.: 189353-31-9
- Formula:C13H14N2O
- Molecular Weight:214.26
IUPAC Name: 3-((1H-imidazol-4-yl)methyl)-2,3-dihydro-1H-inden-5-ol
InChIKey: VTZPAJGVRWKMAG-UHFFFAOYSA-N
SMILES: OC1=CC=C2C(C(CC2)CC3=CN=CN3)=C1
Biological Activity: Fadolmidine is a novel, selective α2-adrenoceptor (α2-AR) agonist with EC50 values of 0.4 nM, 4.9 nM and 0.5 nM for 2A, 2B and 2C, respectively. Fadolmidine has been effective against various submodalities of pain such as heat pain, mechanical pain, and visceral pain. Fadolmidine inhibits also electrically evoked contractions in rat vas deferens[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Fadolmidine | Fadolmidine is a novel, selective α2-adrenoceptor (α2-AR) agonist with EC50 values of 0.4 nM, 4.9 nM and 0.5 nM for 2A, 2B and 2C, respectively. Fadolmidine has been effective against various submodalities of pain such as heat pain, mechanical pain, and visceral pain. Fadolmidine inhibits also electrically evoked contractions in rat vas deferens. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
- [1]. Pertovaara A. Antinociceptive properties of fadolmidine (MPV-2426), a novel alpha2-adrenoceptor agonist. CNS Drug Rev. 2004 Summer;10(2):117-26. [Content Brief]
- [2]. Lehtimäki J, et al. In vitro and in vivo profiling of fadolmidine, a novel potent alpha(2)-adrenoceptor agonist with local mode of action. Eur J Pharmacol. 2008 Dec 3;599(1-3):65-71. [Content Brief]
Keywords
