189498-56-4
Chemical Structure
ABT-080 free base
Synonym(s): VML-530 free base
- CAS No.: 189498-56-4
- Formula:C37H32N2O4
- Molecular Weight:568.66
InChIKey: JZNYKMFUBPEYJE-UHFFFAOYSA-N
SMILES: O=C(CCC(C1=CC=C(C=C1)OCC2=NC3=C(C=C2)C=CC=C3)(C)C4=CC=C(C=C4)OCC5=NC6=C(C=C5)C=CC=C6)O
Biological Activity: ABT-080 free base is an orally active inhibitor of leukotriene biosynthesis that targets 5-lipoxygenase-activating protein (FLAP). ABT-080 free base inhibits leukotriene production in intact human neutrophils, mouse peritoneal macrophages and human whole blood, with IC50 values of 20 nM, 0.16 nM and 13 μM, respectively. ABT-080 free base blocks the leukotriene pathway leading to the synthesis of LTB4 and LTC4, but does not block PGH2 biosynthesis. ABT-080 free base inhibits leukotriene biosynthesis and bronchoconstriction in mouse models. ABT-080 is used in research related to asthma, pleurisy and allergy[1].
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ABT-080 free base | ABT-080 free base is an orally active inhibitor of leukotriene biosynthesis that targets 5-lipoxygenase-activating protein (FLAP). ABT-080 free base inhibits leukotriene production in intact human neutrophils, mouse peritoneal macrophages and human whole blood, with IC50 values of 20 nM, 0.16 nM and 13 μM, respectively. ABT-080 free base blocks the leukotriene pathway leading to the synthesis of LTB4 and LTC4, but does not block PGH2 biosynthesis. ABT-080 free base inhibits leukotriene biosynthesis and bronchoconstriction in mouse models. ABT-080 is used in research related to asthma, pleurisy and allergy. | |||||||||||||||||||||
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Keywords
