190508-48-6
190508-48-6
Chemical Structure
AT-1015
- CAS No.: 190508-48-6
- Formula:C29H36ClN3O3
- Molecular Weight:510.07
InChIKey: HVZWFSFGKOWUSM-UHFFFAOYSA-N
SMILES: O=C(C1CCN(C=O)CC1)NCCN2CC/C(CC2)=C3C4=CC=CC=C4C=CC5=CC=CC=C/35.O.Cl
Biological Activity: AT-1015 is a selective and orally active 5-HT2A serotonin receptor antagonist. AT-1015 exhibits antithrombotic effect. AT-1015 prolongs the time needed to occlusion of the artery with thrombus. AT-1015 impairs platelet aggregation and vasoconstriction[1][2].
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AT-1015 | AT-1015 is a selective and orally active 5-HT2A serotonin receptor antagonist. AT-1015 exhibits antithrombotic effect. AT-1015 prolongs the time needed to occlusion of the artery with thrombus. AT-1015 impairs platelet aggregation and vasoconstriction. | |||||||||||||||||||||
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References
- [1]. Hiatt, W. R., et al., (2004). Randomized trial of AT-1015 for treatment of intermittent claudication. A novel 5-hydroxytryptamine antagonist with no evidence of efficacy. Vascular medicine (London, England), 9(1), 18-25. [Content Brief]
- [2]. Kihara, H., et al., (2001). Antithrombotic activity of AT-1015, a potent 5-HT(2A) receptor antagonist, in rat arterial thrombosis model and its effect on bleeding time. European journal of pharmacology, 433(2-3), 157-162. [Content Brief]
