1906915-49-8
1906915-49-8
Chemical Structure
BQZ-485
- CAS No.: 1906915-49-8
- Formula:C32H39NO3
- Molecular Weight:485.66
InChIKey: ZVIZZPZIASTBPC-QGUTYXHZSA-N
SMILES: CC1=CC(C)=CC(COC2=CC3=C([C@](C[C@@H](O)C[C@@H]4C)([H])N4CC3)C=C2OCC5=CC(C)=CC(C)=C5)=C1
Biological Activity: BQZ-485 is a a potent GDI2 inhibitor through the interaction with Tyr245. BQZ-485 disrupts the intrinsic GDI2-Rab1A interaction, thereby abolishing vesicular transport from the endoplasmic reticulum (ER) to the Golgi apparatus and initiating subsequent paraptosis events[1].
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BQZ-485 | BQZ-485 is a a potent GDI2 inhibitor through the interaction with Tyr245. BQZ-485 disrupts the intrinsic GDI2-Rab1A interaction, thereby abolishing vesicular transport from the endoplasmic reticulum (ER) to the Golgi apparatus and initiating subsequent paraptosis events. | |||||||||||||||||||||
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References
Keywords
