1906919-67-2
1906919-67-2
Chemical Structure
BAY-598
- CAS No.: 1906919-67-2
- Formula:C22H20Cl2F2N6O3
- Molecular Weight:525.34
IUPAC Name: (S,E)-N-(1-(N-cyano-N'-(3-(difluoromethoxy)phenyl)carbamimidoyl)-3-(3,4-dichlorophenyl)-4,5-dihydro-1H-pyrazol-4-yl)-N-ethyl-2-hydroxyacetamide
InChIKey: OTTJIRVZJJGFTK-SFHVURJKSA-N
SMILES: ClC1=C(Cl)C=CC(C2=NN(/C(NC#N)=N/C3=CC=CC(OC(F)F)=C3)C[C@@H]2N(C(CO)=O)CC)=C1
Biological Activity: BAY-598, a chemical probe, is selective small molecule inhibitor of SMYD2 with an IC50 of 27 nM[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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BAY-598 | 99.33% | BAY-598, a chemical probe, is selective small molecule inhibitor of SMYD2 with an IC50 of 27 nM. | ||||||||||||||||||||
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References
- [1]. Reynoird N, et al. Coordination of stress signals by the lysine methyltransferase SMYD2 promotes pancreaticcancer. Genes Dev. 2016 Apr 1;30(7):772-85. [Content Brief]
- [2]. Eggert E, et al. Discovery and Characterization of a Highly Potent and Selective Aminopyrazoline-Based in Vivo Probe (BAY-598) for the Protein Lysine Methyltransferase SMYD2. J Med Chem. 2016 May 26;59(10):4578-600. [Content Brief]
