1928782-31-3
Chemical Structure
Keap1-Nrf2-IN-14
- CAS No.: 1928782-31-3
- Formula:C30H29NO8S
- Molecular Weight:563.62
IUPAC Name: 2-((4-((N-(carboxymethyl)-2,4,6-trimethylphenyl)sulfonamido)naphthalen-1-yl)oxy)-2-(4-methoxyphenyl)acetic acid
InChIKey: SNWXNMFUFJGUTF-UHFFFAOYSA-N
SMILES: O=C(O)C(OC1=C2C=CC=CC2=C(N(CC(O)=O)S(=O)(C3=C(C)C=C(C)C=C3C)=O)C=C1)C4=CC=C(OC)C=C4
Biological Activity: Keap1-Nrf2-IN-14 (compound 20c) is a KEAP1-NRF2 inhibitor that effectively disrupts the KEAP1-NRF2 interaction (IC50=75 nM) with a Kd value of 24 nM for KEAP1. Keap1-Nrf2-IN-14 induces the expression of NRF2 target genes and enhances the downstream antioxidant and anti-inflammatory activities. Keap1-Nrf2-IN-14 can be used in the study of oxidative stress-related inflammation[1].
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Keap1-Nrf2-IN-14 | 98.08% | Keap1-Nrf2-IN-14 (compound 20c) is a KEAP1-NRF2 inhibitor that effectively disrupts the KEAP1-NRF2 interaction (IC50=75 nM) with a Kd value of 24 nM for KEAP1. Keap1-Nrf2-IN-14 induces the expression of NRF2 target genes and enhances the downstream antioxidant and anti-inflammatory activities. Keap1-Nrf2-IN-14 can be used in the study of oxidative stress-related inflammation. | ||||||||||||||||||||
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