193681-12-8
193681-12-8
Chemical Structure
Alamifovir
Synonym(s): LY582563; MCC-478
- CAS No.: 193681-12-8
- Formula:C19H20F6N5O5PS
- Molecular Weight:575.42
IUPAC Name: bis(2,2,2-trifluoroethyl) ((2-(2-amino-6-((4-methoxyphenyl)thio)-9H-purin-9-yl)ethoxy)methyl)phosphonate
InChIKey: VDBGPMJFHCJMOL-UHFFFAOYSA-N
SMILES: COC1=CC=C(C=C1)SC2=C3N=CN(C3=NC(N)=N2)CCOCP(OCC(F)(F)F)(OCC(F)(F)F)=O
Biological Activity: Alamifovir (LY582563; MCC-478), a purine nucleotide analogue proagent, shows potent activity against wild type and lamivudine resistant hepatitis B virus (HBV). Alamifovir has high activity against HBV replication and sustained antiviral effect[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Alamifovir | 95.0% | Alamifovir (LY582563; MCC-478), a purine nucleotide analogue proagent, shows potent activity against wild type and lamivudine resistant hepatitis B virus (HBV). Alamifovir has high activity against HBV replication and sustained antiviral effect. | ||||||||||||||||||||
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References
- [1]. Suzane Kioko Ono-Nita, et al. Novel nucleoside analogue MCC-478 (LY582563) is effective against wild-type or lamivudine-resistant hepatitis B virus. Antimicrob Agents Chemother. 2002 Aug;46(8):2602-5. [Content Brief]
- [2]. Danny K W Soon, et al. Safety and efficacy of alamifovir in patients with chronic hepatitis B virus infection. J Hepatol. 2004 Nov;41(5):852-8. [Content Brief]
