195068-07-6
195068-07-6
Chemical Structure
Sarizotan hydrochloride
Synonym(s): EMD 128130 hydrochloride
- CAS No.: 195068-07-6
- Formula:C22H22ClFN2O
- Molecular Weight:384.87
IUPAC Name: (R)-1-(chroman-2-yl)-N-((5-(4-fluorophenyl)pyridin-3-yl)methyl)methanamine hydrochloride
InChIKey: QDLVYMYXOLGZOD-ZMBIFBSDSA-N
SMILES: FC1=CC=C(C2=CN=CC(CNC[C@H]3CCC4=CC=CC=C4O3)=C2)C=C1.Cl[H]
Biological Activity: Sarizotan hydrochloride is an orally active serotonin 5-HT1A receptor and dopamine receptor agonist. Sarizotan hydrochloride (EMD 128130) exhibits IC50 values of 6.5 nM (rat 5-HT1A), 0.1 nM (human 5-HT1A), 15.1 nM (rat D2), 17 nM (human D2), 6.8 nM (human D3) and 2.4 nM (human D4.2), respectively[1].
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Sarizotan hydrochloride | Sarizotan hydrochloride is an orally active serotonin 5-HT1A receptor and dopamine receptor agonist. Sarizotan hydrochloride (EMD 128130) exhibits IC50 values of 6.5 nM (rat 5-HT1A), 0.1 nM (human 5-HT1A), 15.1 nM (rat D2), 17 nM (human D2), 6.8 nM (human D3) and 2.4 nM (human D4.2), respectively. | |||||||||||||||||||||
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