1955-67-5
1955-67-5
Chemical Structure
L-Glutamic γ-monohydroxamate
- CAS. Nr.: 1955-67-5
- Formula:C5H10N2O4
- Molecular Weight:162.14
IUPAC Name: N5-hydroxy-L-glutamine
InChIKey: YVGZXTQJQNXIAU-VKHMYHEASA-N
SMILES: N[C@H](C(O)=O)CCC(NO)=O
Biological Activity: L-Glutamic γ-monohydroxamate is an antitumor agent, inhibits cell proliferation. L-Glutamic γ-monohydroxamate selectively inhibits the uptake of L-histidine into microvascular endothelial cell. L-Glutamic γ-monohydroxamate, as a vanadium ligand, activates glucose uptake and metabolism, thus decreases the blood glucose levels in vivo[1][2][3].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
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L-Glutamic γ-monohydroxamate | 99.66% | L-Glutamic γ-monohydroxamate is an antitumor agent, inhibits cell proliferation. L-Glutamic γ-monohydroxamate selectively inhibits the uptake of L-histidine into microvascular endothelial cell. L-Glutamic γ-monohydroxamate, as a vanadium ligand, activates glucose uptake and metabolism, thus decreases the blood glucose levels in vivo. | ||||||||||||||||||||
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References
- [1]. Vila J, et al. In vitro and in vivo anti-tumor activity of L-glutamic acid gamma-monohydroxamate against L1210 leukemia and B16 melanoma. Int J Cancer. 1990 Apr 15;45(4):737-43. [Content Brief]
- [2]. Sakurai E, et al. Stereoselective transport of histidine in rat lung microvascular endothelial cells. Am J Physiol Lung Cell Mol Physiol. 2002 Jun;282(6):L1192-7. [Content Brief]
- [3]. Goldwaser I, et al. L-Glutamic acid gamma-monohydroxamate. A potentiator of vanadium-evoked glucose metabolism in vitro and in vivo. J Biol Chem. 1999 Sep 10;274(37):26617-24. [Content Brief]
Keywords
