1962925-29-6
Chemical Structure
Nirogacestat dihydrobromide
Synonym(s): PF-3084014 dihydrobromide; PF-03084014 dihydrobromide
- CAS No.: 1962925-29-6
- Formula:C27H43Br2F2N5O
- Molecular Weight:651.47
IUPAC Name: (S)-2-(((S)-6,8-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl)amino)-N-(1-(2-methyl-1-(neopentylamino)propan-2-yl)-1H-imidazol-4-yl)pentanamide dihydrobromide
InChIKey: LXEYYZYDWLAIPW-KBVFCZPLSA-N
SMILES: FC1=C2C(CC[C@H](N[C@@H](CCC)C(NC3=CN(C(C)(C)CNCC(C)(C)C)C=N3)=O)C2)=CC(F)=C1.Br.Br
Biological Activity: Nirogacestat dihydrobromide (PF-3084014 dihydrobromide) is a reversible, orally bioavailable, noncompetitive, and selective γ-secretase inhibitor with an IC50 of 6.2 nM. Inhibition of Notch signaling by Nirogacestat dihydrobromide while minimizing gastrointestinal toxicity presents a promising approach for research of Notch receptor-dependent cancers[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Nirogacestat dihydrobromide | 99.81% | Nirogacestat dihydrobromide (PF-3084014 dihydrobromide) is a reversible, orally bioavailable, noncompetitive, and selective γ-secretase inhibitor with an IC50 of 6.2 nM. Inhibition of Notch signaling by Nirogacestat dihydrobromide while minimizing gastrointestinal toxicity presents a promising approach for research of Notch receptor-dependent cancers. | ||||||||||||||||||||
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