1970269-96-5
1970269-96-5
Chemical Structure
EGFR/microtubule-IN-1
- CAS. Nr.: 1970269-96-5
- Formula:C23H18BrN5O3
- Molecular Weight:492.32
InChIKey: ISXTYIKHFRPNMX-UHFFFAOYSA-N
SMILES: O=C(NC(NC1=C(OC)C=C(N=CN=C2NC3=CC=C(Br)C=C3)C2=C1)=O)C4=CC=CC=C4
Biological Activity: EGFR/microtubule-IN-1 (Compound 10c) is a dual inhibitor targeting EGFR and tubulin. The IC50 for inhibiting EGFR is 10.66 nM. EGFR/microtubule-IN-1 can reduce the phosphorylation levels of EGFR, AKT and ERK, hinder tubulin polymerization, and induce apoptosis[1].
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EGFR/microtubule-IN-1 | EGFR/microtubule-IN-1 (Compound 10c) is a dual inhibitor targeting EGFR and tubulin. The IC50 for inhibiting EGFR is 10.66 nM. EGFR/microtubule-IN-1 can reduce the phosphorylation levels of EGFR, AKT and ERK, hinder tubulin polymerization, and induce apoptosis. | |||||||||||||||||||||
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References
Keywords
