EGFR/microtubule-IN-1
EGFR/microtubule-IN-1 (Compound 10c) is a dual inhibitor targeting EGFR and tubulin. The IC50 for inhibiting EGFR is 10.66 nM. EGFR/microtubule-IN-1 can reduce the phosphorylation levels of EGFR, AKT and ERK, hinder tubulin polymerization, and induce apoptosis.
For research use only. We do not sell to patients.
- CAS No.: 1970269-96-5
- Formula: C23H18BrN5O3
- Molecular Weight:492.32
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All EGFR Isoforms
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Biological Activity
10.66 nM (EGFR)[1]
Chemical Information
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CAS No. 1970269-96-5
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Molecular Weight 492.32
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Formula C23H18BrN5O3
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SMILES
O=C(NC(NC1=C(OC)C=C(N=CN=C2NC3=CC=C(Br)C=C3)C2=C1)=O)C4=CC=CC=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)