1980821-53-1
1980821-53-1
Chemical Structure
pan-Raf/RTK inhibitor 1
- CAS No.: 1980821-53-1
- Formula:C29H28F3N7O3
- Molecular Weight:579.57
InChIKey: JJZOMHGFHHDWQO-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C(C)C(NC(C2(CC2)C3=NC=NC4=C3NC=N4)=O)=C1)NC5=CC=C(CN6CCOCC6)C(C(F)(F)F)=C5
Biological Activity: Pan-Raf/RTK inhibitor 1 (compound I-16) is a potent pan-Raf inhibitor with IC50 values of 3.49 nM (BRafV600E), 8.86 nM (ARaf), 5.78 nM (BRafWT), and 1.65 nM (CRaf). Pan-Raf/RTK inhibitor 1 exhibits antiproliferative activities against various cancer cell lines and can be utilized in cancer research[1].
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pan-Raf/RTK inhibitor 1 | Pan-Raf/RTK inhibitor 1 (compound I-16) is a potent pan-Raf inhibitor with IC50 values of 3.49 nM (BRafV600E), 8.86 nM (ARaf), 5.78 nM (BRafWT), and 1.65 nM (CRaf). Pan-Raf/RTK inhibitor 1 exhibits antiproliferative activities against various cancer cell lines and can be utilized in cancer research. | |||||||||||||||||||||
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References
Keywords
