1987883-24-8
Chemical Structure
2'-Deoxyadenosine-13C10,15N5
- No. CAS: 1987883-24-8
- Formula:13C10H1315N5O3
- Molecular Weight:266.14
InChIKey: OLXZPDWKRNYJJZ-FTPQRVEMSA-N
SMILES: [15NH2][13C]1=[15N][13CH]=[15N][13C]2=[13C]1[15N]=[13CH][15N]2[13C@H]3[13CH]([H])[13C@H](O)[13C@@H]([13CH2]O)O3
Biological Activity: 2'-Deoxyadenosine-13C10,15N5 is 13C and 15N-labeled 2'-Deoxyadenosine (HY-W040329)[1]. 2′-Deoxyadenosine is an adenine nucleoside that inhibits glucose-stimulated insulin release. 2′-Deoxyadenosine inhibits glucose-stimulated increases seen in islet cyclic AMP (cAMP) accumulation. 2'-Deoxyadenosine activates caspase-3 and promotes apoptosis. 2'-Deoxyadenosine inhibits the activity of S-adenosyl-L-homocysteine hydrolase (SAHH). 2'-Deoxyadenosine inhibits the growth of various cells. 2'-Deoxyadenosine has an anticancer effect on colon cancer[2][3][4].
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2'-Deoxyadenosine-13C10,15N5 | 2'-Deoxyadenosine-13C10,15N5 is 13C and 15N-labeled 2'-Deoxyadenosine (HY-W040329). 2′-Deoxyadenosine is an adenine nucleoside that inhibits glucose-stimulated insulin release. 2′-Deoxyadenosine inhibits glucose-stimulated increases seen in islet cyclic AMP (cAMP) accumulation. 2'-Deoxyadenosine activates caspase-3 and promotes apoptosis. 2'-Deoxyadenosine inhibits the activity of S-adenosyl-L-homocysteine hydrolase (SAHH). 2'-Deoxyadenosine inhibits the growth of various cells. 2'-Deoxyadenosine has an anticancer effect on colon cancer. | |||||||||||||||||||||
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- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
- [2]. Iain L. Campbell, et al. Effects of adenosine, 2-deoxyadenosine and N6-phenylisopropyladenosine on rat islet function and metabolism. Biochem J (1982) 204 (3): 689-696. [Content Brief]
- [3]. Giannecchini M, et al. 2'-Deoxyadenosine causes apoptotic cell death in a human colon carcinoma cell line. J Biochem Mol Toxicol. 2003;17(6):329-37. [Content Brief]
- [4]. Cass CE, et al. Effects of 2'-deoxyadenosine, 9-beta-D-arabinofuranosyladenine, and related compounds on S-adenosyl-L-homocysteine hydrolase activity in synchronous and asynchronous cultured cells. Cancer Res. 1982 Dec;42(12):4991-8. [Content Brief]
Keywords
