199522-35-5
199522-35-5
Chemical Structure
NNC 26-9100
- CAS No.: 199522-35-5
- Formula:C22H25BrCl2N6S
- Molecular Weight:556.35
IUPAC Name: 1-(3-(1H-imidazol-5-yl)propyl)-3-(3-((5-bromopyridin-2-yl)(3,4-dichlorobenzyl)amino)propyl)thiourea
InChIKey: UREJDUPKGMFJRU-UHFFFAOYSA-N
SMILES: S=C(NCCCC1=CN=CN1)NCCCN(C2=NC=C(Br)C=C2)CC3=CC=C(Cl)C(Cl)=C3
Biological Activity: NNC 26-9100 is a selective somatostatin sst4 receptor full agonist (Ki: 6 nM, EC50: 2 nM). NNC 26-9100 decreases total soluble Aβ42, increases brain neprilysin activity and improves learning[1][2].
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NNC 26-9100 | 99.3% | NNC 26-9100 is a selective somatostatin sst4 receptor full agonist (Ki: 6 nM, EC50: 2 nM). NNC 26-9100 decreases total soluble Aβ42, increases brain neprilysin activity and improves learning. | ||||||||||||||||||||
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References
- [1]. Michael Ankersen, et al. Discovery of a Novel Non-Peptide Somatostatin Agonist with SST4 Selectivity. J. Am. Chem. Soc. 1998, 120, 7, 1368-1373.
- [2]. Sandoval KE, et al. Somatostatin receptor subtype-4 agonist NNC 26-9100 mitigates the effect of soluble Aβ(42) oligomers via a metalloproteinase-dependent mechanism. Brain Res. 2013 Jul 3;1520:145-56. [Content Brief]
Keywords
