199854-00-7
199854-00-7
Chemical Structure
O-Acetylsalicylhydroxamic acid
- CAS No.: 199854-00-7
- Formula:C9H9NO4
- Molecular Weight:195.17
InChIKey: PCFWLDHLJWUGSU-UHFFFAOYSA-N
SMILES: O=C(C)ONC(C1=C(O)C=CC=C1)=O
Biological Activity: O-Acetylsalicylhydroxamic acid is an acetylation inhibitor of prostaglandin H2 synthase that can suppress PGE2 synthesis in the body and block the cyclooxygenase activity of PGHS in vitro. O-Acetylsalicylhydroxamic acid requires the presence of the active site residue Ser-529 to act on human PGHS-1; the S529A mutant is resistant to the inactivation effects of this inhibitor[1].
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O-Acetylsalicylhydroxamic acid | O-Acetylsalicylhydroxamic acid is an acetylation inhibitor of prostaglandin H2 synthase that can suppress PGE2 synthesis in the body and block the cyclooxygenase activity of PGHS in vitro. O-Acetylsalicylhydroxamic acid requires the presence of the active site residue Ser-529 to act on human PGHS-1; the S529A mutant is resistant to the inactivation effects of this inhibitor. | |||||||||||||||||||||
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References
Keywords
