2007110-15-6
2007110-15-6
Chemical Structure
PD1-PDL1-IN-4
- CAS No.: 2007110-15-6
- Formula:C19H25N5O6
- Molecular Weight:419.43
InChIKey: XIYKWOOOEYTRIY-HJPIBITLSA-N
SMILES: OC(C=C1)=CC=C1C[C@@H](C2=NC([C@@H](N)[C@@H](O)C)=NO2)NC(N3[C@@H](CCC3)C(O)=O)=O
Biological Activity: PD1-PDL1-IN-4 (compound 19) is a potent and orally active PD1-PDL1 inhibitor that modulates TIGIT and PD-1 signalling pathways. PD1-PDL1-IN-4 can rescue CD8+ T cell and mouse splenocyte proliferation. PD1-PDL1-IN-4 inhibits tumor growth in a CT26 syngeneic colon adenocarcinoma mouse model. PD1-PDL1-IN-4 can be used for research on colon cancer[1].
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PD1-PDL1-IN-4 | PD1-PDL1-IN-4 (compound 19) is a potent and orally active PD1-PDL1 inhibitor that modulates TIGIT and PD-1 signalling pathways. PD1-PDL1-IN-4 can rescue CD8+ T cell and mouse splenocyte proliferation. PD1-PDL1-IN-4 inhibits tumor growth in a CT26 syngeneic colon adenocarcinoma mouse model. PD1-PDL1-IN-4 can be used for research on colon cancer. | |||||||||||||||||||||
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