202925-60-8
Chemical Structure
Conantokin R
Synonym(s): Con-R
- CAS No.: 202925-60-8
- Formula:C127H201N35O49S3
- Molecular Weight:3098.35
SMILES: OC(C=C1)=CC=C1C[C@H](NC([C@H]2NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CSSC2)NC(CNC([C@H](CCCCN)NC([C@H](C)NC([C@H]([C@@H](C)CC)NC([C@H](CC(N)=O)NC([C@H](CC(C(O)=O)C(O)=O)NC([C@H](CCCNC(N)=N)NC([C@H](C)NC([C@H](CC(C)C)NC([C@@H](NC([C@H](C)NC([C@H](C)NC([C@H](CCSC)NC([C@H](CCCCN)NC([C@H](C)NC([C@H](C(C)C)NC([C@H](CC(C(O)=O)C(O)=O)NC([C@H](CC(C(O)=O)C(O)=O)NC([C@H](CCC(O)=O)NC(CN)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC(C(O)=O)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CCCCN)=O)C(C)C)=O)CC(N)=O)=O)=O)C(N3[C@@H](CCC3)C(O)=O)=O
Biological Activity: Conantokin R (Con-R) is an NMDA receptor peptide antagonist with an IC50 of 93 nM. Conantokin R binds Zn2+ and Mg2+ with Kds of 0.15 μM and 6.5 μM, respectively. Conantokin R shows anticonvulsant activity[1][2].
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Conantokin R | Conantokin R (Con-R) is an NMDA receptor peptide antagonist with an IC50 of 93 nM. Conantokin R binds Zn2+ and Mg2+ with Kds of 0.15 μM and 6.5 μM, respectively. Conantokin R shows anticonvulsant activity. | |||||||||||||||||||||
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References
- [1]. Blandl T, et al. Structure-function relationships of the NMDA receptor antagonist peptide, conantokin-R. FEBS Lett. 2000 Mar 24;470(2):139-46. [Content Brief]
- [2]. White HS, et al. In vitro and in vivo characterization of conantokin-R, a selective NMDA receptor antagonist isolated from the venom of the fish-hunting snail Conus radiatus. J Pharmacol Exp Ther. 2000 Jan;292(1):425-32. [Content Brief]
