Conantokin R (Synonyms: Con-R)

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Conantokin R (Con-R) is an NMDA receptor peptide antagonist with an IC₅₀ of 93 nM. Conantokin R binds Zn²⁺ and Mg²⁺ with K_ds of 0.15 μM and 6.5 μM, respectively. Conantokin R shows anticonvulsant activity.

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Conantokin R Chemical Structure

CAS No. : 202925-60-8

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Description	Conantokin R (Con-R) is an NMDA receptor peptide antagonist with an IC₅₀ of 93 nM. Conantokin R binds Zn²⁺ and Mg²⁺ with K_ds of 0.15 μM and 6.5 μM, respectively. Conantokin R shows anticonvulsant activity^[1]^[2].
IC₅₀ & Target	IC50: 93 nM (NMDA receptor)^[1]
Molecular Weight	3098.35
Formula	C₁₂₇H₂₀₁N₃₅O₄₉S₃
CAS No.	202925-60-8
Sequence	Gly-Glu-{Gla}-{Gla}-Val-Ala-Lys-Met-Ala-Ala-{Gla}-Leu-Ala-Arg-{Gla}-Asn-Ile-Ala-Lys-Gly-Cys-Lys-Val-Asn-Cys-Tyr-Pro (Disulfide bridge:Cys21-Cys25)
Sequence Shortening	GE-{Gla}-{Gla}-VAKMAA-{Gla}-LAR-{Gla}-NIAKGCKVNCYP (Disulfide bridge:Cys21-Cys25)
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (260 KB) Handling Instructions (2659 KB)
References	[1]. Blandl T, et al. Structure-function relationships of the NMDA receptor antagonist peptide, conantokin-R. FEBS Lett. 2000 Mar 24;470(2):139-46. [Content Brief] [2]. White HS, et al. In vitro and in vivo characterization of conantokin-R, a selective NMDA receptor antagonist isolated from the venom of the fish-hunting snail Conus radiatus. J Pharmacol Exp Ther. 2000 Jan;292(1):425-32. [Content Brief]

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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Conantokin R202925-60-8Con-RiGluRIonotropic glutamate receptorsanticonvulsantConus radiatusInhibitorinhibitorinhibit

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Conantokin R (Synonyms: Con-R)

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