2030410-25-2
2030410-25-2
Chemical Structure
Glasdegib maleate
Synonym(s): PF-04449913 maleate
- CAS No.: 2030410-25-2
- Formula:C25H26N6O5
- Molecular Weight:490.51
IUPAC Name: 1-((2R,4R)-2-(1H-benzo[d]imidazol-2-yl)-1-methylpiperidin-4-yl)-3-(4-cyanophenyl)urea maleate
InChIKey: VJCVKWFBWAVYOC-UIXXXISESA-N
SMILES: O=C(NC1=CC=C(C#N)C=C1)N[C@H]2C[C@H](C3=NC4=CC=CC=C4N3)N(C)CC2.OC(/C=C\C(O)=O)=O
Biological Activity: Glasdegib maleate (PF-04449913 maleate) is a potent and orally bioavailable smoothened inhibitor. Glasdegib maleate binds to human SMO (amino acids 181-787) with IC50value of 4 nM[1].
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Glasdegib maleate | Glasdegib maleate (PF-04449913 maleate) is a potent and orally bioavailable smoothened inhibitor. Glasdegib maleate binds to human SMO (amino acids 181-787) with IC50value of 4 nM. | |||||||||||||||||||||
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