20408-97-3
Chemical Structure
Thioglucose
- CAS No.: 20408-97-3
- Formula:C6H12O5S
- Molecular Weight:196.22
IUPAC Name: (2R,3R,4S,5R)-2,3,4,6-tetrahydroxy-5-mercaptohexanal
InChIKey: IJJLRUSZMLMXCN-SLPGGIOYSA-N
SMILES: OC[C@@H](S)[C@@H](O)[C@H](O)[C@@H](O)C=O
Biological Activity: Thioglucose is a thiosugar with antioxidant properties. Thioglucose acts as an H2S/polysulfide donor to elevate intracellular sulfane sulfur levels and promote hydropersulfide formation. Thioglucose reduces the endocytosis of gold nanoparticles by phagocytes, enhances cytotoxicity and improves biocompatibility by increasing their adsorption on the surface of cancer cells. Thioglucose can be engineered into a stimulus-responsive prodrug or functional reagent for the development of targeted nanocarriers, and is used in studies related to human breast adenocarcinoma and cervical cancer[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Thioglucose | 99.97% | Thioglucose is a thiosugar with antioxidant properties. Thioglucose acts as an H2S/polysulfide donor to elevate intracellular sulfane sulfur levels and promote hydropersulfide formation. Thioglucose reduces the endocytosis of gold nanoparticles by phagocytes, enhances cytotoxicity and improves biocompatibility by increasing their adsorption on the surface of cancer cells. Thioglucose can be engineered into a stimulus-responsive prodrug or functional reagent for the development of targeted nanocarriers, and is used in studies related to human breast adenocarcinoma and cervical cancer. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
- [1]. Lindahl S, et al. Thioglucose-derived tetrasulfide, a unique polysulfide model compound. Redox Biol. 2024;70:103045. [Content Brief]
- [2]. Ni X, et al. A Sweet H2S/H2O2 Dual Release System and Specific Protein S-Persulfidation Mediated by Thioglucose/Glucose Oxidase. J Am Chem Soc. 2021;143(33):13325-13332. [Content Brief]
- [3]. Tomaszewska E, et al. Systematic studies of gold nanoparticles functionalised with thioglucose and its cytotoxic effect[J]. ChemistrySelect, 2021, 6(6): 1230-1237.
Keywords
