204919-14-2
Chemical Structure
IDN-1965
- CAS No.: 204919-14-2
- Formula:C21H26FN3O5
- Molecular Weight:419.45
IUPAC Name: 3-((S)-2-(1,3-dimethyl-1H-indole-2-carboxamido)-3-methylbutanamido)-5-fluoro-4-oxopentanoic acid
InChIKey: GONUYDANRODTCF-IBYPIGCZSA-N
SMILES: O=C(CC(C(CF)=O)NC([C@H](C(C)C)NC(C(N1C)=C(C2=C1C=CC=C2)C)=O)=O)O
Biological Activity: IDN-1965 is an irreversible, broad-spectrum caspase inhibitor. IDN-1965 prevents downstream apoptotic events (such as DNase activation) and significantly delays cytochrome c release by inhibiting caspase activity. IDN-1965 significantly delayed death in mice with cardiomyocyte apoptosis. IDN-1965 completely prevents left ventricular dilation, systolic dysfunction, and fibrosis in mice with dilated cardiomyopathy. IDN-1965 can be used to study apoptosis-related diseases such as heart failure and the mechanisms of apoptosis initiation[1][2].
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IDN-1965 | IDN-1965 is an irreversible, broad-spectrum caspase inhibitor. IDN-1965 prevents downstream apoptotic events (such as DNase activation) and significantly delays cytochrome c release by inhibiting caspase activity. IDN-1965 significantly delayed death in mice with cardiomyocyte apoptosis. IDN-1965 completely prevents left ventricular dilation, systolic dysfunction, and fibrosis in mice with dilated cardiomyopathy. IDN-1965 can be used to study apoptosis-related diseases such as heart failure and the mechanisms of apoptosis initiation. | |||||||||||||||||||||
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References
- [1]. Wencker D, et al. A mechanistic role for cardiac myocyte apoptosis in heart failure. J Clin Invest. 2003 May;111(10):1497-504. [Content Brief]
- [2]. Marsden VS,et al. Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome. Nature. 2002 Oct 10;419(6907):634-7. [Content Brief]
