2057420-29-6
2057420-29-6
Chemical Structure
BRD9185
- CAS No.: 2057420-29-6
- Formula:C23H21F6N3O2
- Molecular Weight:485.42
IUPAC Name: (2S,3S,4S)-3-(3',4'-bis(trifluoromethyl)-[1,1'-biphenyl]-4-yl)-2-cyano-4-(hydroxymethyl)-N-propylazetidine-1-carboxamide
InChIKey: FYPZBZFXJUJJRA-AQNXPRMDSA-N
SMILES: O=C(N1[C@@H]([C@H]([C@H]1C#N)C2=CC=C(C3=CC=C(C(C(F)(F)F)=C3)C(F)(F)F)C=C2)CO)NCCC
Biological Activity: BRD9185 is a Dihydroorotate dehydrogenase (DHODH) inhibitor, with an EC50 of 16 nM against multidrug-resistant blood-stage parasites in vitro and is curative after just three doses in a P. berghei mouse model[1].
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BRD9185 | BRD9185 is a Dihydroorotate dehydrogenase (DHODH) inhibitor, with an EC50 of 16 nM against multidrug-resistant blood-stage parasites in vitro and is curative after just three doses in a P. berghei mouse model. | |||||||||||||||||||||
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