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BRD9185 

Cat. No.: HY-120924
Handling Instructions

BRD9185 is a Dihydroorotate dehydrogenase (DHODH) inhibitor, with an EC50 of 16 nM against multidrug-resistant blood-stage parasites in vitro and is curative after just three doses in a P. berghei mouse model.

For research use only. We do not sell to patients.

BRD9185 Chemical Structure

BRD9185 Chemical Structure

CAS No. : 2057420-29-6

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Description

BRD9185 is a Dihydroorotate dehydrogenase (DHODH) inhibitor, with an EC50 of 16 nM against multidrug-resistant blood-stage parasites in vitro and is curative after just three doses in a P. berghei mouse model[1].

IC50 & Target

EC50: 16 nM (DHODH in vitro)[1].

Molecular Weight

485.42

Formula

C₂₃H₂₁F₆N₃O₂

CAS No.

2057420-29-6

SMILES

O=C(N1[[email protected]@H]([[email protected]]([[email protected]]1C#N)C2=CC=C(C3=CC=C(C(C(F)(F)F)=C3)C(F)(F)F)C=C2)CO)NCCC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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BRD9185
Cat. No.:
HY-120924
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