206648-13-7
Chemical Structure
CGP-78608
- CAS No.: 206648-13-7
- Formula:C11H13BrN3O5P
- Molecular Weight:378.12
IUPAC Name: (S)-(1-(((7-bromo-2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-yl)methyl)amino)ethyl)phosphonic acid
InChIKey: DPFHVUSPVHRVFL-YFKPBYRVSA-N
SMILES: C[C@H](P(O)(O)=O)NCC1=CC(Br)=CC(NC2=O)=C1NC2=O
Biological Activity: CGP 78608 is a highly potent and selective antagonist at the glycine-binding site of the NMDA receptor, with an IC50 of 6 nM. CGP 78608 acts as a potentiator of GluN1/GluN3A-mediated glycine currents, with an estimated EC50 in the low nM range (26.3 nM). CGP 78608 has anticonvulsant activities[1][2].
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CGP-78608 | CGP 78608 is a highly potent and selective antagonist at the glycine-binding site of the NMDA receptor, with an IC50 of 6 nM. CGP 78608 acts as a potentiator of GluN1/GluN3A-mediated glycine currents, with an estimated EC50 in the low nM range (26.3 nM). CGP 78608 has anticonvulsant activities. | |||||||||||||||||||||
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Keywords
