2088112-70-1
2088112-70-1
Chemical Structure
XO44
Synonym(s): PF-6808472
- CAS No.: 2088112-70-1
- Formula:C25H27FN8O3S
- Molecular Weight:538.60
IUPAC Name: 4-((4-(4-((5-cyclopropyl-1H-pyrazol-3-yl)amino)-6-(prop-2-yn-1-ylcarbamoyl)pyrimidin-2-yl)piperazin-1-yl)methyl)benzenesulfonyl fluoride
InChIKey: ZBSPMOBILDLOCV-UHFFFAOYSA-N
SMILES: O=S(C1=CC=C(CN2CCN(C3=NC(C(NCC#C)=O)=CC(NC4=NNC(C5CC5)=C4)=N3)CC2)C=C1)(F)=O
Biological Activity: XO44 (PF-6808472) is a broad-spectrum covalent kinase probe. XO44 can bind in CDK2 and CDK1. XO44 also labels CDK4 proteins in cells[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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XO44 | 99.73% | XO44 (PF-6808472) is a broad-spectrum covalent kinase probe. XO44 can bind in CDK2 and CDK1. XO44 also labels CDK4 proteins in cells. | ||||||||||||||||||||
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References
- [1]. Kevin D Freeman-Cook, et al. Discovery of PF-06873600, a CDK2/4/6 Inhibitor for the Treatment of Cancer. J Med Chem. 2021 Jul 8;64(13):9056-9077. [Content Brief]
- [2]. Guiley KZ, et al. p27 allosterically activates cyclin-dependent kinase 4 and antagonizes palbociclib inhibition. Science. 2019 Dec 13;366(6471):eaaw2106. [Content Brief]
