2089334-01-8
Chemical Structure
PF-06745013
- CAS No.: 2089334-01-8
- Formula:C21H19ClN2O3
- Molecular Weight:382.84
IUPAC Name: 2-(4-(6-amino-5-(4-chlorophenyl)pyridin-3-yl)phenoxy)-2-methylpropanoic acid
InChIKey: BYWYWLKBKIJAAJ-UHFFFAOYSA-N
SMILES: O=C(C(C)(C)OC1=CC=C(C2=CN=C(C(C3=CC=C(Cl)C=C3)=C2)N)C=C1)O
Biological Activity: PF-06745013 (Compound 37) is a MAP4K4 inhibitor without time-dependent inhibition (TDI) risk of CYP3A4 (IC50 of 0.4 nM for MAP4K4). PF-06745013 has no accumulation CNS-impaired and non-ATP competitive activities in mouse models. PF-06745013 can be used for inflammatory diseases like diabetes and cancers research[1].
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PF-06745013 | PF-06745013 (Compound 37) is a MAP4K4 inhibitor without time-dependent inhibition (TDI) risk of CYP3A4 (IC50 of 0.4 nM for MAP4K4). PF-06745013 has no accumulation CNS-impaired and non-ATP competitive activities in mouse models. PF-06745013 can be used for inflammatory diseases like diabetes and cancers research. | |||||||||||||||||||||
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Keywords
