2091995-55-8
2091995-55-8
Chemical Structure
ISIS 626112
Synonym(s): ION-626112
- CAS No.: 2091995-55-8
- Formula:N/A
- Molecular Weight:7152.75
SMILES: [ISIS 626112]
Biological Activity: ISIS 626112 (ION-626112) is a blood-brain barrier-permeable MOE-gapmer antisense oligonucleotide and also an inhibitor of the Malat1 long non-coding RNA. ISIS 626112 triggers RNase H1-mediated cleavage and degradation of complementary Malat1 RNA. ISIS 626112 dose-dependently reduces Malat1 RNA levels in all tested central nervous system regions and major central nervous system cell types in mice, with glial cells showing higher sensitivity than neurons[1][2].
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ISIS 626112 | ISIS 626112 (ION-626112) is a blood-brain barrier-permeable MOE-gapmer antisense oligonucleotide and also an inhibitor of the Malat1 long non-coding RNA. ISIS 626112 triggers RNase H1-mediated cleavage and degradation of complementary Malat1 RNA. ISIS 626112 dose-dependently reduces Malat1 RNA levels in all tested central nervous system regions and major central nervous system cell types in mice, with glial cells showing higher sensitivity than neurons. | |||||||||||||||||||||
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References
- [1]. Kawanobe T, et al. Improved efficacy and tolerability of antisense oligonucleotide with Guanidine-bridged nucleic acid[J]. bioRxiv, 2026: 2026.01. 08.698310.
- [2]. Jafar-Nejad P, et al. The atlas of RNase H antisense oligonucleotide distribution and activity in the CNS of rodents and non-human primates following central administration. Nucleic acids research. 2021 Jan 25;49(2):657-673. [Content Brief]
