2093677-54-2
2093677-54-2
Chemical Structure
MWAC-3429
- No. CAS: 2093677-54-2
- Formula:C22H23N3O2S
- Molecular Weight:393.50
InChIKey: XIZPDIBGQDVIBF-UHFFFAOYSA-N
SMILES: COC1=CC2=C(CC(N(C2)C(C3=CSC(CCN)=N3)=O)C4=CC=CC=C4)C=C1
Biological Activity: MWAC-3429 is a potent SARS-CoV-2 Nsp13 helicase inhibitor. MWAC-3429 inhibits SARS-CoV-2 and SARS-CoV1 with EC50s of 5.39 (nLuc assay) and 17.00 μM (CPE assay), respectively, while showing low cytotoxicity in A549-hACE2 cells (CC50 > 50 μM). MWAC-3429 can be used for SARS-CoV-infection research[1].
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MWAC-3429 | MWAC-3429 is a potent SARS-CoV-2 Nsp13 helicase inhibitor. MWAC-3429 inhibits SARS-CoV-2 and SARS-CoV1 with EC50s of 5.39 (nLuc assay) and 17.00 μM (CPE assay), respectively, while showing low cytotoxicity in A549-hACE2 cells (CC50 > 50 μM). MWAC-3429 can be used for SARS-CoV-infection research. | |||||||||||||||||||||
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References
Keywords
