2095-20-7
2095-20-7
Chemical Structure
Desmonomethylpromazine
- CAS No.: 2095-20-7
- Formula:C16H18N2S
- Molecular Weight:270.39
IUPAC Name: N-methyl-3-(10H-phenothiazin-10-yl)propan-1-amine
InChIKey: WOCOVPRTRIBGFZ-UHFFFAOYSA-N
SMILES: CNCCCN1C2=C(C=CC=C2)SC3=C1C=CC=C3
Biological Activity: Desmonomethylpromazine is the brain-penetrant demethylated metabolite of Promazine (HY-B1225A). Desmonomethylpromazine can enter red blood cells and tissues through passive diffusion, distributes in tissues such as lung, liver, and kidney in rats[1][2].
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Desmonomethylpromazine | Desmonomethylpromazine is the brain-penetrant demethylated metabolite of Promazine (HY-B1225A). Desmonomethylpromazine can enter red blood cells and tissues through passive diffusion, distributes in tissues such as lung, liver, and kidney in rats. | |||||||||||||||||||||
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References
- [1]. Daniel KRAPPMANN, et al. Selective inhibition of malt1 protease by phenothiazine derivatives. WO2013017637A1. 2013-02-07.
- [2]. Hu OY, et al. Stability, human blood distribution and rat tissue localization of promazine and desmonomethylpromazine. Biopharm Drug Dispos. 1989 Nov-Dec;10(6):537-48. [Content Brief]
Keywords
