2095514-84-2
2095514-84-2
Chemical Structure
TP-030-2
- CAS No.: 2095514-84-2
- Formula:C23H21BrN4O3
- Molecular Weight:481.34
IUPAC Name: (S)-3-(2-benzyl-3-bromo-7-oxo-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)-5-methyl-2,3-dihydrobenzo[b][1,4]oxazepin-4(5H)-one
InChIKey: KHVVJKLNKLQLJZ-SFHVURJKSA-N
SMILES: O=C1C2=NN(CC3=CC=CC=C3)C(Br)=C2CCN1[C@@H]4C(N(C5=CC=CC=C5OC4)C)=O
Biological Activity: TP-030-2, a chemical probe, is a RIPK1 inhibitor (human Ki=0.43 nM; mouse IC50=100 nM)[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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TP-030-2 | 98.17% | TP-030-2, a chemical probe, is a RIPK1 inhibitor (human Ki=0.43 nM; mouse IC50=100 nM). | ||||||||||||||||||||
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References
- [1]. Yoshikawa M, et al. Discovery of 7-Oxo-2,4,5,7-tetrahydro-6 H-pyrazolo[3,4- c]pyridine Derivatives as Potent, Orally Available, and Brain-Penetrating Receptor Interacting Protein 1 (RIP1) Kinase Inhibitors: Analysis of Structure-Kinetic Relationships. J Med Chem. 2018 Mar 22;61(6):2384-2409. [Content Brief]
- [2]. https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/TP-030-2
