2123481-48-9
2123481-48-9
Chemical Structure
UNC2383
- CAS No.: 2123481-48-9
- Formula:C22H21ClN4O2
- Molecular Weight:408.88
InChIKey: IOJAPRVYOPUKQU-UHFFFAOYSA-N
SMILES: O=C(C(O1)=CC2=C1C=CC(Cl)=C2)NC3=NC4=CC=CC=C4N3CCN5CCCC5
Biological Activity: UNC2383 is an oligonucleotide enhancer compound. UNC2383 can enhance the efficacy of antisense oligonucleotides (ASOs) and splice-switching oligonucleotides (SSOs). UNC2383 can be used in research of diseases involving impaired oligonucleotide delivery, such as cystic fibrosis[1][2][3].
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UNC2383 | 98.68% | UNC2383 is an oligonucleotide enhancer compound. UNC2383 can enhance the efficacy of antisense oligonucleotides (ASOs) and splice-switching oligonucleotides (SSOs). UNC2383 can be used in research of diseases involving impaired oligonucleotide delivery, such as cystic fibrosis. | ||||||||||||||||||||
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References
- [1]. Ling Wang, et al. A Novel Family of Small Molecules that Enhance the Intracellular Delivery and Pharmacological Effectiveness of Antisense and Splice Switching Oligonucleotides. ACS Chem Biol. 2017 Aug 18;12(8):1999-2007. [Content Brief]
- [2]. Munson MJ, et al. A high-throughput Galectin-9 imaging assay for quantifying nanoparticle uptake, endosomal escape and functional RNA delivery. Commun Biol. 2021 Feb 16;4(1):211. [Content Brief]
- [3]. Dang Y, et al. Enhanced delivery of peptide-morpholino oligonucleotides with a small molecule to correct splicing defects in the lung. Nucleic Acids Res. 2021 Jun 21;49(11):6100-6113. [Content Brief]
Keywords
