213126-92-2
Chemical Structure
(±)5,6-DHET lactone
Synonym(s): (±)5,6-DiHETrE lactone
- CAS No.: 213126-92-2
- Formula:C20H32O3
- Molecular Weight:320.47
IUPAC Name: 6-((3Z,6Z,9Z)-1-hydroxypentadeca-3,6,9-trien-1-yl)tetrahydro-2H-pyran-2-one
InChIKey: FVXUUVSFGPLNBJ-QNEBEIHSSA-N
SMILES: O=C1CCCC(C(O)C/C=C\C/C=C\C/C=C\CCCCC)O1
Biological Activity: 5,6-DiHET lactone ((±)5,6-DiHETrE lactone) is a lactonized form of 5,6-EET and 5,6-DiHET. In solution, 5(6)-EET degrades into 5(6)-DiHET and 5(6)-δ-lactone, which can be converted to 5(6)-DiHET and quantified by GC-MS.1 5,6-DiHET potently induces vasodilation of isolated canine coronary arterioles, with 41 and 100% inhibition occurring at 0.01 and 100 pM, respectively. It also induces vasodilation in isolated human microvessels and increases intracellular calcium levels in a dose-dependent manner, an effect that can be blocked by the nitric oxide scavenger L-NAME.
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(±)5,6-DHET lactone | 5,6-DiHET lactone ((±)5,6-DiHETrE lactone) is a lactonized form of 5,6-EET and 5,6-DiHET. In solution, 5(6)-EET degrades into 5(6)-DiHET and 5(6)-δ-lactone, which can be converted to 5(6)-DiHET and quantified by GC-MS.1 5,6-DiHET potently induces vasodilation of isolated canine coronary arterioles, with 41 and 100% inhibition occurring at 0.01 and 100 pM, respectively. It also induces vasodilation in isolated human microvessels and increases intracellular calcium levels in a dose-dependent manner, an effect that can be blocked by the nitric oxide scavenger L-NAME. | |||||||||||||||||||||
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