2135341-09-0
2135341-09-0
Chemical Structure
LX-039
- CAS No.: 2135341-09-0
- Formula:C27H20Cl2FNO2
- Molecular Weight:480.36
IUPAC Name: (E)-3-(4-((Z)-1-(3-chloro-1H-indol-2-yl)-2-(2-chloro-4-fluorophenyl)but-1-en-1-yl)phenyl)acrylic acid
InChIKey: HUQVRIJCSRWPQV-HPTDBUQXSA-N
SMILES: O=C(O)/C=C/C1=CC=C(/C(C(N2)=C(Cl)C3=C2C=CC=C3)=C(C4=CC=C(F)C=C4Cl)\CC)C=C1
Biological Activity: LX-039 is a highly potent, selective and orally active estrogen receptor degrader with EC50 value of 2.29 nM. LX-039 has indole C-3 chlorine atom. LX-039 exhibits excellent mouse pharmacokinetics, low clearance, high Cmax and oral exposure. LX-039 has anti-tumor activity[1].
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LX-039 | LX-039 is a highly potent, selective and orally active estrogen receptor degrader with EC50 value of 2.29 nM. LX-039 has indole C-3 chlorine atom. LX-039 exhibits excellent mouse pharmacokinetics, low clearance, high Cmax and oral exposure. LX-039 has anti-tumor activity. | |||||||||||||||||||||
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