2140-72-9
2140-72-9
Chemical Structure
2'-O-Methylcytidine
- CAS No.: 2140-72-9
- Formula:C10H15N3O5
- Molecular Weight:257.25
IUPAC Name: 4-amino-1-((2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)pyrimidin-2(1H)-one
InChIKey: RFCQJGFZUQFYRF-ZOQUXTDFSA-N
SMILES: O[C@H]1[C@@H](OC)[C@H](N2C(N=C(N)C=C2)=O)O[C@@H]1CO
Biological Activity: 2'-O-Methylcytidine is an orally active 2'-substituted nucleoside as a inhibitor of HCV replication with antiviral activity. 2'-O-Methylcytidine inhibits RNA-dependent RNA polymerase (NS5B)-catalyzed RNA synthesis in vitro, in a manner that is competitive with substrate nucleoside triphosphate[1][2][3].
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2'-O-Methylcytidine | 99.71% | 2'-O-Methylcytidine is an orally active 2'-substituted nucleoside as a inhibitor of HCV replication with antiviral activity. 2'-O-Methylcytidine inhibits RNA-dependent RNA polymerase (NS5B)-catalyzed RNA synthesis in vitro, in a manner that is competitive with substrate nucleoside triphosphate. | ||||||||||||||||||||
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2'-O-Methylcytidine (Standard) | 99.71% | 2'-O-Methylcytidine (Standard) is the analytical standard of 2'-O-Methylcytidine. This product is intended for research and analytical applications. 2'-O-Methylcytidine is an orally active 2'-substituted nucleoside as a inhibitor of HCV replication with antiviral activity. 2'-O-Methylcytidine inhibits RNA-dependent RNA polymerase (NS5B)-catalyzed RNA synthesis in vitro, in a manner that is competitive with substrate nucleoside triphosphate. | ||||||||||||||||||||
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References
- [1]. Steven S Carroll, et al. Inhibition of hepatitis C virus RNA replication by 2'-modified nucleoside analogs. J Biol Chem. 2003 Apr 4;278(14):11979-84 [Content Brief]
- [2]. Hingerty B, et al. The crystal and molecular structure of 2'-O-methylcytidine[J]. Acta Crystallographica Section B: Structural Crystallography and Crystal Chemistry, 1977, 33(5): 1349-1356.
- [3]. Del Vecchio AM, et al. Small molecule and biologic inhibitors of hepatitis C virus: a symbiotic approach. Mini Rev Med Chem. 2006 Nov;6(11):1263-8. [Content Brief]
