2154342-17-1
Chemical Structure
Thalidomide-4-NH-PEG1-NH-Boc
- CAS. Nr.: 2154342-17-1
- Formula:C22H28N4O7
- Molecular Weight:460.48
IUPAC Name: 4,4'-((2R,3R)-2,3-dimethylbutane-1,4-diyl)bis(2-methoxyphenol)
InChIKey: DGINBGUHHXNCBY-UHFFFAOYSA-N
SMILES: O=C(OC(C)(C)C)NCCOCCNC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O
Biological Activity: Thalidomide-4-NH-PEG1-NH-Boc is a Boc-modified Thalidomide (HY-14658) that acts as a Cereblon ligand to recruit CRBN protein. The Boc protecting group at the end of Thalidomide-4-NH-PEG1-NH-Boc can be removed under acidic conditions to participate in the synthesis of PROTAC molecules. Thalidomide-4-NH-PEG1-NH-Boc is a key intermediate in the synthesis of CRBN-based PROTAC molecules.
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Thalidomide-4-NH-PEG1-NH-Boc | Thalidomide-4-NH-PEG1-NH-Boc is a Boc-modified Thalidomide (HY-14658) that acts as a Cereblon ligand to recruit CRBN protein. The Boc protecting group at the end of Thalidomide-4-NH-PEG1-NH-Boc can be removed under acidic conditions to participate in the synthesis of PROTAC molecules. Thalidomide-4-NH-PEG1-NH-Boc is a key intermediate in the synthesis of CRBN-based PROTAC molecules. | |||||||||||||||||||||
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Keywords
