217176-91-5
Chemical Structure
Caged MK801
- CAS No.: 217176-91-5
- Formula:C26H24N2O6
- Molecular Weight:460.48
InChIKey: WZDXUEMCALAOAY-ATIYNZHBSA-N
SMILES: COC(C=C1COC(N2[C@@H]3CC4=C([C@]2(C)C5=CC=CC=C53)C=CC=C4)=O)=C(C=C1[N+]([O-])=O)OC
Biological Activity: Caged MK801 is a photolabile NMDA receptor open-channel blocker. Caged MK801 releases MK801 upon photolysis activation, producing use-dependent blockade of NMDA receptor currents and synaptic NMDA receptor-mediated currents. Caged MK801 releases MK801 by photolysis in the postsynaptic region (somatodendritic region), which blocks the induction of timing-dependent long-term potentiation (t-LTP). Caged MK801 can be used in research related to neurological diseases[1][2].
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Caged MK801 | Caged MK801 is a photolabile NMDA receptor open-channel blocker. Caged MK801 releases MK801 upon photolysis activation, producing use-dependent blockade of NMDA receptor currents and synaptic NMDA receptor-mediated currents. Caged MK801 releases MK801 by photolysis in the postsynaptic region (somatodendritic region), which blocks the induction of timing-dependent long-term potentiation (t-LTP). Caged MK801 can be used in research related to neurological diseases. | |||||||||||||||||||||
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References
- [1]. Rodríguez-Moreno A, et al. Presynaptic induction and expression of timing-dependent long-term depression demonstrated by compartment-specific photorelease of a use-dependent NMDA receptor antagonist. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2011 Jun 08;31(23):8564-8569. [Content Brief]
- [2]. Reeve JE, et al. Caged intracellular NMDA receptor blockers for the study of subcellular ion channel function. Communicative & integrative biology. 2012 May 01;5(3):240-2. [Content Brief]
