217950-62-4
Chemical Structure
GW 275175X
- CAS No.: 217950-62-4
- Formula:C12H11BrCl2N2O4
- Molecular Weight:398.04
IUPAC Name: (2R,3R,4R,5R)-2-(2-bromo-5,6-dichloro-1H-benzo[d]imidazol-1-yl)tetrahydro-2H-pyran-3,4,5-triol
InChIKey: OOAVDXDURLPULP-GWOFURMSSA-N
SMILES: O[C@H]1[C@H](N2C3=CC(Cl)=C(Cl)C=C3N=C2Br)OC[C@@H](O)[C@H]1O
Biological Activity: GW 275175X is an inhibitor of the terminase complex involved in cleavage and packaging of the unit length DNA into the capsids. GW 275175X exhibits long plasma half-life. GW 275175X is a BDCRB derivative. GW 275175X exhibits anti-HCMV activity through inhibiting maturation of viral DNA[1][2][3].
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GW 275175X | GW 275175X is an inhibitor of the terminase complex involved in cleavage and packaging of the unit length DNA into the capsids. GW 275175X exhibits long plasma half-life. GW 275175X is a BDCRB derivative. GW 275175X exhibits anti-HCMV activity through inhibiting maturation of viral DNA. | |||||||||||||||||||||
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- [1]. Emery, V. C., & Hassan-Walker, A. F. (2002). Focus on new drugs in development against human cytomegalovirus. Drugs, 62(13), 1853-1858. [Content Brief]
- [2]. Williams, S. L., et al., (2003). In vitro activities of benzimidazole D- and L-ribonucleosides against herpesviruses. Antimicrobial agents and chemotherapy, 47(7), 2186-2192. [Content Brief]
- [3]. McGregor, A., & Choi, K. Y. (2011). Cytomegalovirus antivirals and development of improved animal models. Expert opinion on drug metabolism & toxicology, 7(10), 1245-1265. [Content Brief]
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