21804-29-5
Chemical Structure
D-3-Hydroxybutyryl-CoA
Synonym(s): D-β-Hydroxybutyryl-CoA
- CAS No.: 21804-29-5
- Formula:C25H42N7O18P3S
- Molecular Weight:853.62
InChIKey: QHHKKMYHDBRONY-WZZMXTMRSA-N
SMILES: C[C@@H](O)CC(SCCNC(CCNC([C@H](O)C(C)(C)COP(OP(O)(OC[C@H]1O[C@@H](N2C=NC3=C(N)N=CN=C32)[C@H](O)[C@@H]1OP(O)(O)=O)=O)(O)=O)=O)=O)=O
Biological Activity: D-3-Hydroxybutyryl-CoA (D-β-Hydroxybutyryl-CoA) is a thioester compound formed by the combination of coenzyme A and D-3-Hydroxybutyryl, and is a key intermediate metabolite in microbial butyrate metabolism and polymer synthesis pathways. D-3-Hydroxybutyryl-CoA plays a central role in intracellular carbon storage, lipid metabolism, and energy conversion processes. D-3-Hydroxybutyryl-CoA is mainly generated from Acetyl-CoA through catalysis by reductase, and can subsequently either be dehydrated by 3-Hydroxybutyryl-CoA dehydratase into Crotonyl-CoA to participate in further metabolism, or be directly polymerized by PHA synthase to form the macromolecular cellular energy storage material PHB. D-3-Hydroxybutyryl-CoA can be used in metabolic engineering of biodegradable plastics in synthetic biology and in research on the regulatory mechanisms of microbial carbon metabolism[1][2][3].
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D-3-Hydroxybutyryl-CoA | D-3-Hydroxybutyryl-CoA (D-β-Hydroxybutyryl-CoA) is a thioester compound formed by the combination of coenzyme A and D-3-Hydroxybutyryl, and is a key intermediate metabolite in microbial butyrate metabolism and polymer synthesis pathways. D-3-Hydroxybutyryl-CoA plays a central role in intracellular carbon storage, lipid metabolism, and energy conversion processes. D-3-Hydroxybutyryl-CoA is mainly generated from Acetyl-CoA through catalysis by reductase, and can subsequently either be dehydrated by 3-Hydroxybutyryl-CoA dehydratase into Crotonyl-CoA to participate in further metabolism, or be directly polymerized by PHA synthase to form the macromolecular cellular energy storage material PHB. D-3-Hydroxybutyryl-CoA can be used in metabolic engineering of biodegradable plastics in synthetic biology and in research on the regulatory mechanisms of microbial carbon metabolism. | |||||||||||||||||||||
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References
- [1]. Olavarria K, et al. An NADH preferring acetoacetyl-CoA reductase is engaged in poly-3-hydroxybutyrate accumulation in Escherichia coli. Journal of biotechnology. 2021 Jan 10;325:207-216.
- [2]. Sami N, et al. Estrone degrading enzymes of CPCC-695 and synthesis of bioplastic precursor as a by-product. Biotechnology reports (Amsterdam, Netherlands). 2020 Jun;26:e00464.
- [3]. Kamravamanesh D, et al. Increased poly-β-hydroxybutyrate production from carbon dioxide in randomly mutated cells of cyanobacterial strain Synechocystis sp. PCC 6714: Mutant generation and characterization. Bioresource technology. 2018 Oct;266:34-44.
