2187430-05-1
Chemical Structure
Batoclimab
Synonym(s): RVT-1401; HBM9161; IMVT-1401
- CAS No.: 2187430-05-1
- Formula:N/A
- Molecular Weight:(143.43 kDa)
IUPAC Name: 2,5-dioxopyrrolidin-1-yl 5-((4-(((2-amino-7H-purin-6-yl)oxy)methyl)benzyl)amino)-5-oxopentanoate
SMILES: [Batoclimab]
Biological Activity: Batoclimab (RVT-1401) is a fully humanized IgG1 monoclonal antibody targeting FcRn. Batoclimab has high affinity for the IgG-binding site on FcRn. By competitively binding to the IgG binding site on FcRn, Batoclimab blocks FcRn-mediated recycling of IgG, resulting in enhanced degradation and subsequent reductions in IgG levels. Batoclimab can be used in the research of autoimmune diseases such as myasthenia gravis and thyroid eye disease[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Batoclimab | 99.89% | Batoclimab (RVT-1401) is a fully humanized IgG1 monoclonal antibody targeting FcRn. Batoclimab has high affinity for the IgG-binding site on FcRn. By competitively binding to the IgG binding site on FcRn, Batoclimab blocks FcRn-mediated recycling of IgG, resulting in enhanced degradation and subsequent reductions in IgG levels. Batoclimab can be used in the research of autoimmune diseases such as myasthenia gravis and thyroid eye disease. | ||||||||||||||||||||
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- [1]. Yan C, et, al. Therapeutic Effects of Batoclimab in Chinese Patients with Generalized Myasthenia Gravis: A Double-Blinded, Randomized, Placebo-Controlled Phase II Study. Neurol Ther. 2022 Apr 12. [Content Brief]
- [2]. Kahaly GJ, et al. Proof-of-concept and Randomized, Placebo-controlled Trials of an FcRn Inhibitor, Batoclimab, for Thyroid Eye Disease. J Clin Endocrinol Metab. 2023 Nov 17;108(12):3122-3134. [Content Brief]
Keywords
