219501-57-2
219501-57-2
Chemical Structure
AMP423
- CAS. Nr.: 219501-57-2
- Formula:C14H11N3O
- Molecular Weight:237.26
IUPAC Name: 2-cyano-N-(naphthalen-1-yl)aziridine-1-carboxamide
InChIKey: WTPBNYGXGYMXNL-UHFFFAOYSA-N
SMILES: O=C(NC1=C2C=CC=CC2=CC=C1)N3C(C3)C#N
Biological Activity: AMP423 is an oxidation inducer and cell cycle regulator. AMP423 induces necrosis, apoptosis, and reactive oxygen species production. AMP423 induces inhibition of protein synthesis, reduction of thiol levels, and S-phase cell accumulation, and exhibits antitumor activity. AMP423 can be used in research related to multiple myeloma and follicular B-cell lymphoma[1][2].
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AMP423 | AMP423 is an oxidation inducer and cell cycle regulator. AMP423 induces necrosis, apoptosis, and reactive oxygen species production. AMP423 induces inhibition of protein synthesis, reduction of thiol levels, and S-phase cell accumulation, and exhibits antitumor activity. AMP423 can be used in research related to multiple myeloma and follicular B-cell lymphoma. | |||||||||||||||||||||
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References
- [1]. Dorr RT, et al. Anti-tumor activity and mechanism of action for a cyanoaziridine-derivative, AMP423. Cancer chemotherapy and pharmacology. 2012 Apr;69(4):1039-49. [Content Brief]
- [2]. Hilz E N, et al. Conditioned orienting predicts preference for, and affective response to, amphetamine after multiple exposures in male rats[J]. bioRxiv, 2025: 2025.09. 06.674656.
